A review exploring the mechanisms of Campylobacter jejuni adhesion

Jerica Sabotič and Nika Janež, in collaboration with Anja Klančnik from the Biotechnical faculty at University of Ljubljana, have recently published a review paper entitled »Molecular structures mediating adhesion of Campylobacter jejuni to abiotic and biotic surfaces”, which provides a comprehensive overview of the molecular and functional aspects of adhesion of C. jejuni, which is a key factor in the pathogenesis and persistence of this bacterium, the leading cause of bacterial gastroenteritis worldwide. The review describes the different structures and interactions that mediate the adhesion of C. jejuni to various surfaces, including hosts and abiotic materials. It also discusses the diversity and distribution of adhesion proteins among C. jejuni strains from different ecological niches and identifies some potential new adhesion factors that have not yet been explored. The study emphasizes that protein-protein, protein-glycan and glycan-glycan interactions are essential for adhesion, with different factors contributing differently under different conditions. The authors emphasize the importance of integrating different approaches and methods to gain a better understanding of the adhesion process and its role in the biology and epidemiology of C. jejuni. By considering the multiple and interconnected roles of proteins, glycoconjugates and polysaccharides, we aim to refine strategies to effectively control C. jejuni and reduce its public health burden.
Link: https://doi.org/10.1016/j.vetmic.2023.109918

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