New inhibitors of cathepsin V

• Post by: Ana Mitrović
• 9.September, 2022
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In paper entitled »New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity« published in Computational and Structural Biotechnology Journal (IF = 6.155) members of the department Ana Mitrović, Emanuela Senjor, Mateja Prunk, Milica Perišić Nanut and Janko Kos joint forces with medicinal chemists from Department of Pharmaceutical Chemistry, University of Ljubljana, Faculty of Pharmacy in identification of novel potent selective inhibitors of lysosomal cysteine peptidase cathepsin V that demonstrated antitumor activity. New inhibitors impair tumor cell proliferation and elastase degradation and increase immune cell cytotoxicity. Cathepsin V inhibitor also impaired conversion of immunosuppressive factor cystatin F to its active monomeric form.

The paper is available at: https://lnkd.in/d4qNHSAM