Fungal lectins show differential antiproliferative activity against cancer cells
- Post by: Ana Mitrović
- 14.April, 2025
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We announce the publication of our study in the International Journal of Biological Macromolecules. The study, led by Dr. Jerica Sabotič in collaboration with colleagues from the Department of Biochemistry and Molecular and Structural Biology of the Jožef Stefan Institute and the BioLab at the IUBO of the University of La Laguna, Santa Cruz de Tenerife, Canary Islands, investigated the antiproliferative activity of fungal lectins against different cancer cell lines. We discovered that some lectins showed indiscriminate antiproliferative activity in all cell lines tested, while others showed differential antiproliferative activity. The study provides valuable insights into the unique properties and mechanisms of fungal lectins and highlights their potential as diagnostic or therapeutic agents in cancer treatment. The innovative approach of the study, using continuous live cell imaging and high-content analysis, provides a comprehensive understanding of the effects of fungal lectins on cancer cells. This joint work was made possible by the EMBO Scientific Grant and supported by the government of Spain and the Slovenian Research and Innovation Agency. For more details, you can view the full study here: https://doi.org/10.1016/j.ijbiomac.2024.139220