Approaches to the treatment of Clostridioides difficile infection

• Post by: Ana Mitrović
• 12.July, 2024
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Abida Zahirović, Borut Štrukelj and Aleš Berlec from the Department of Biotechnology at the Jožef Stefan Institute, in collaboration with colleagues from the Faculty of Pharmacy at the University of Ljubljana and the National Laboratory for Health, Environment and Food, have prepared a comprehensive article on approaches to the treatment of Clostridioides difficile infection that do not involve antibiotics or faecal transplantation, and published it in the prestigious journal Gut Microbes. The new approaches include modulation of the gut microbiota, neutralisation of bacterial toxins, modulation of the immune response and direct bactericidal action, and use, among others, antibodies, defined bacterial mixtures, bacteriophages and low-molecular-weight non-antibiotic agents. Although the active substances are at different stages of development, some monoclonal antibodies and defined bacterial mixtures are already registered as drugs.
Link: https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2337312