Disease relevance of nucleocytoplasmic shuttling

• Post by: Ana Mitrović
• 21.June, 2021
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Prof. Rogelj in collaboration with colleagues from King’s College London published a review article on disease relevance of nucleocytoplasmic shuttling in the esteemed journal Brain (IF 13.5). Abnormalities in expression and function of proteins that are involved in nucleocytoplasmic shuttling called karyopherins can be both the cause and consequence of protein mislocalisation and aggregate formation in many diseases characterised by pathological protein accumulation. Pharmacological targeting of karyopherins, already in clinical trials as therapeutic intervention targeting cancers such as glioblastoma and viral infections including COVID-19, represent a promising new avenue for disease-modifying treatments in neurodegenerative diseases as well. https://pubmed.ncbi.nlm.nih.gov/34019093/