Contact Information

Call: +386 1 477 34 11


Prof. Boris Rogelj, PhD

Head of department

Research intersts
Molecular basis of neurological disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), Prader—Willi syndrome (PWS) and others.
• Function and regulation of RNA-binding proteins in ALS and FTD.
• Nuclear transport of RNA and proteins.
• Cellular stress response.
• RNA and protein interactomes.
• Structure and function of noncanonical DNA and RNA.
• Role of ncRNAs in neurodegeneration.
• Genetics of ALS and FTD.
• RNA-RNA interactome of snoRNAs associated with PWS.

Major scientific achievements
• Identified mutations in genes coding for TDP-43 and FUS in sporadic and familial ALS.
• Neuropathological characterization of TDP-43, FUS, optineurin and C9orf72 in ALS and/or FTD.
• Characterized RNA binding properties and nuclear transport of TDP-43 and FUS.
• Showed that mutant FUS has propensity to form stress granules.
• Defined phosphorylation of 526Y of FUS as important for mislocalization.
• Shown that the sense strand DNA of C9orf72 can form G-quadruplexes, while the antisense strand can form i-motifs/protonated hairpins.
• Characterized the proteins that bind to the sense strand of C9orf72 repeat RNA.
• Determined changes in microRNA associated with muscle atrophy in ALS.
• Lead of Slovenian section in international consortia for genetic characterization of ALS and FTD.
• Showed involvement of orphan snoRNAs in learning and memory.

2019- Head of Department of Biotechnology – Jožef Stefan Institute, Ljubljana, Slovenia
2013- University teacher – Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia
2011- Research group leader / Scientific consultant – Biomedical Research Institute, Ljubljana, Slovenia
2011-2019 Scientific associate / Research group leader – Jožef Stefan Institute, Ljubljana, Slovenia
2007-2011 Senior research associate / status of lecturer – Dept. of Clinical Neuroscience, Institute of Psychiatry, King’s College London, UK
2003-2007 Senior postdoctoral researcher – Dept. of Neuroscience, Institute of Psychiatry, King’s College London, UK
2000-2003 Research fellow – Dept. of Anatomy and Developmental Biology and Wolfson Institute for Biomedical Research, University College London, UK
1999-2000 Postdoctoral researcher – Dept. of Biochemistry and Mol. Biology, Jožef Stefan Institute, Ljubljana, Slovenia

Major awards:
• 2019 Prestigious national Zois recognition for contribution to the development of science and research in the Republic of Slovenia in the field of molecular neurodegeneration.
• 2017 Lapanje award from Slovenian Biochemical Society for exceptional scientific, educational and professional achievements in the field of Biochemical Sciences.

Current grants as PI:
• Regulation of intracellular complexes formed by dipeptide repeats from C9ORF72 mutation. CRP-ICGEB, 2020-2022; €45,000.
• N3-0141 Nuclear transport defects in frontotemporal dementia. Lead Agency: Hungarian National Research, Development and Innovation Office / Slovenian Research Agency; 2020-2022; €109,275.
• J3-9263 Role of paraspeckle like nuclear bodies in pathogenesis of ALS and FTD. Slovenian Research Agency; 2018-2021; €300,000.
• J3-8201 Nuclear transport defects in neurodegenerative diseases. Slovenian Research Agency; 2017-2020; €300,000.