{"id":534,"date":"2020-04-23T15:27:49","date_gmt":"2020-04-23T14:27:49","guid":{"rendered":"https:\/\/wp.modronebo.net\/ijs2\/?post_type=team&p=534"},"modified":"2024-07-29T15:23:32","modified_gmt":"2024-07-29T13:23:32","slug":"prof-boris-rogelj","status":"publish","type":"team","link":"https:\/\/www-b3.ijs.si\/index.php\/rushmore_teams\/prof-boris-rogelj\/","title":{"rendered":"Prof. Boris Rogelj, PhD"},"content":{"rendered":"\n

Research intersts<\/strong>
Molecular basis of neurological disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease (AD), Prader\u2014Willi syndrome (PWS) and others.
\u2022 Function and regulation of RNA-binding proteins in ALS and FTD.
\u2022 Nuclear transport of RNA and proteins.
\u2022 Cellular stress response.
\u2022 RNA and protein interactomes.
\u2022 Structure and function of noncanonical DNA and RNA.
\u2022 Role of ncRNAs in neurodegeneration.
\u2022 Genetics of ALS and FTD.
\u2022 RNA-RNA interactome of snoRNAs associated with PWS.<\/p>\n\n\n\n

Major scientific achievements<\/strong>
\u2022 Identified mutations in genes coding for TDP-43 and FUS in sporadic and familial ALS.
\u2022 Neuropathological characterization of TDP-43, FUS, optineurin and C9orf72 in ALS and\/or FTD.
\u2022 Characterized RNA binding properties and nuclear transport of TDP-43 and FUS.
\u2022 Showed that mutant FUS has propensity to form stress granules.
\u2022 Defined phosphorylation of 526Y of FUS as important for mislocalization.
\u2022 Shown that the sense strand DNA of C9orf72 can form G-quadruplexes, while the antisense strand can form i-motifs\/protonated hairpins.
\u2022 Characterized the proteins that bind to the sense strand of C9orf72 repeat RNA.
\u2022 Determined changes in microRNA associated with muscle atrophy in ALS.
\u2022 Lead of Slovenian section in international consortia for genetic characterization of ALS and FTD.
\u2022 Showed involvement of orphan snoRNAs in learning and memory.<\/p>\n\n\n\n

Appointments:<\/strong>
2019- Head of Department of Biotechnology – Jo\u017eef Stefan Institute, Ljubljana, Slovenia
2013- University teacher – Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia
2011- Research group leader \/ Scientific consultant – Biomedical Research Institute, Ljubljana, Slovenia
2011-2019 Scientific associate \/ Research group leader – Jo\u017eef Stefan Institute, Ljubljana, Slovenia
2007-2011 Senior research associate \/ status of lecturer – Dept. of Clinical Neuroscience, Institute of Psychiatry, King\u2019s College London, UK
2003-2007 Senior postdoctoral researcher – Dept. of Neuroscience, Institute of Psychiatry, King\u2019s College London, UK
2000-2003 Research fellow – Dept. of Anatomy and Developmental Biology and Wolfson Institute for Biomedical Research, University College London, UK
1999-2000 Postdoctoral researcher – Dept. of Biochemistry and Mol. Biology, Jo\u017eef Stefan Institute, Ljubljana, Slovenia<\/p>\n\n\n\n

Major awards:<\/strong>
\u2022 2019 Prestigious national Zois recognition for contribution to the development of science and research in the Republic of Slovenia in the field of molecular neurodegeneration.
\u2022 2017 Lapanje award from Slovenian Biochemical Society for exceptional scientific, educational and professional achievements in the field of Biochemical Sciences.<\/p>\n\n\n\n

Current grants as PI:<\/strong>
\u2022 Regulation of intracellular complexes formed by dipeptide repeats from C9ORF72 mutation. CRP-ICGEB, 2020-2022; \u20ac45,000.
\u2022 N3-0141 Nuclear transport defects in frontotemporal dementia. Lead Agency: Hungarian National Research, Development and Innovation Office \/ Slovenian Research Agency; 2020-2022; \u20ac109,275.
\u2022 J3-9263 Role of paraspeckle like nuclear bodies in pathogenesis of ALS and FTD. Slovenian Research Agency; 2018-2021; \u20ac300,000.
\u2022 J3-8201 Nuclear transport defects in neurodegenerative diseases. Slovenian Research Agency; 2017-2020; \u20ac300,000.<\/p>\n","protected":false},"featured_media":0,"template":"","team_cat":[23],"_links":{"self":[{"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/team\/534"}],"collection":[{"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/team"}],"about":[{"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/types\/team"}],"wp:attachment":[{"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/media?parent=534"}],"wp:term":[{"taxonomy":"team_cat","embeddable":true,"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/team_cat?post=534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}