{"id":1824,"date":"2022-09-09T15:32:26","date_gmt":"2022-09-09T13:32:26","guid":{"rendered":"https:\/\/www-b3.ijs.si\/?p=1824"},"modified":"2022-09-09T15:32:26","modified_gmt":"2022-09-09T13:32:26","slug":"new-inhibitors-of-cathepsin-v","status":"publish","type":"post","link":"https:\/\/www-b3.ijs.si\/index.php\/2022\/09\/09\/new-inhibitors-of-cathepsin-v\/","title":{"rendered":"New inhibitors of cathepsin V"},"content":{"rendered":"\n<p>In paper entitled \u00bbNew inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity\u00ab published in Computational and Structural Biotechnology Journal (IF = 6.155) members of the department Ana Mitrovi\u0107, Emanuela Senjor, Mateja Prunk, Milica Peri\u0161i\u0107 Nanut and Janko Kos joint forces with medicinal chemists from Department of Pharmaceutical Chemistry, University of Ljubljana, Faculty of Pharmacy in identification of novel potent selective inhibitors of lysosomal cysteine peptidase cathepsin V that demonstrated antitumor activity. New inhibitors impair tumor cell proliferation and elastase degradation and increase immune cell cytotoxicity. Cathepsin V inhibitor also impaired conversion of immunosuppressive factor cystatin F to its active monomeric form.<\/p>\n\n\n\n<p>The paper is available at: <a href=\"https:\/\/lnkd.in\/d4qNHSAM\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/lnkd.in\/d4qNHSAM<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In paper entitled \u00bbNew inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity\u00ab published in Computational and Structural Biotechnology Journal (IF = 6.155) members of the department Ana Mitrovi\u0107, Emanuela Senjor, Mateja Prunk, Milica Peri\u0161i\u0107 Nanut and Janko Kos joint forces with medicinal chemists from Department of Pharmaceutical [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":1821,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/posts\/1824"}],"collection":[{"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/comments?post=1824"}],"version-history":[{"count":1,"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/posts\/1824\/revisions"}],"predecessor-version":[{"id":1825,"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/posts\/1824\/revisions\/1825"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/media\/1821"}],"wp:attachment":[{"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/media?parent=1824"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/categories?post=1824"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www-b3.ijs.si\/index.php\/wp-json\/wp\/v2\/tags?post=1824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}